منابع مشابه
Tumour glycolysis: the many faces of HIF.
We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular ...
متن کاملmicroRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma...
متن کاملThe pH-dependence of sugar-transport and glycolysis in cultured Ehrlich ascites-tumour cells.
1. pH-dependence of glycolysis has generally been ascribed to the effects of pH on the activities of glycolytic enzymes. The present study shows that sugar transport is pH-dependent in cultured Ehrlich ascites-tumour cells. 2. The rates of glucose consumption, of 3-O-methylglucose transport, and of 2-deoxyglucose transport and phosphorylation increased as linear functions of pH, as the pH of th...
متن کاملFactors influencing the anaerobic glycolysis of brain and tumour.
Laszt, L. 1945 Helv. physiol, acta, 3, 291. Longmuir, I. S. & Roughton, F. J . W. 1952 J • Physiol. 118, 264. Muller, A. 1945 Helv. physiol, acta, 3, 203. Muller, A. 1948 Helv. physiol, acta, 6, 21. Nicholson, P. & Roughton, F . J . W. 1951 Proc. Roy. Soc. B, 138, 241. O’Brien, G. G., Hyman, M. A. & Kaplan, S. 1951 Math. Phys. 29, 223. Pircher, L. 1951 Thesis, Fribourg. Pircher, L. 1952 Helv. p...
متن کاملA note on the action of tannin upon tumour glycolysis.
Considerations dealing with the relation between cell proliferation and carbohydrate metabolism (particularly that of glucose), as well as with certain effects of variation in the water content of growing tissue, have suggested that the intensity of carbohydrate breakdown in proliferating cells is largely dependent upon the degree of hydration of corresponding enzyme proteins, in such a manner ...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2018
ISSN: 1759-5029,1759-5037
DOI: 10.1038/s41574-018-0017-1